Cyclist Sarah Storey kicks off the action as she goes for the first of four possible golds in the individual C5 pursuit, and European champion Ben Quilter is one of Britain’s best hopes of a judo gold.
Double world champion 'Hurricane' Hannah Cockroft will battle for gold in the T34 100m wheelchair race, while Jody Cundy and Jon-Allan Butterworth go head-to-head in the newly-combined C4/5 1km time trial.
Swimming's golden girl Ellie Simmonds defends the first of her two Paralympic titles in the S6 400m freestyle, and Lee Pearson could win his 10th equestrian gold medal when he competes in the individual 1b test.
Swimmer Sascha Kindred looks to continue an unbeaten run in global championships stretching back to 1998 in the SM6 200m individual medley. On the track, can world record holder Mickey Bushell sprint to golden glory in the T53 100m?
Archer Danielle Brown is back in Paralympic competition to defend her individual compound title, and it’s the first medal day in boccia with Britain expecting to be challenging for the team BC1/2, BC4 pairs and BC3 pairs.
The fast and furious 'murderball' (AKA wheelchair rugby) gets underway and Great Britain are relying on Aaron Phipps to rack up some points. Plus, in the pool, British team-mates and friends Liz Johnson and Charlotte Henshaw do battle in the 100m breaststroke SB6.
Brace yourselves, because #ThrillerThursday has arrived!
Oscar ‘Blade Runner’ Pistorius defends his T44 100m title against the USA’s Jerome Singleton and ParalympicsGB’s Jonnie Peacock, who recently knocked 0.06 seconds off the world record. David Weir will be out to retain his T54 800m title, while Libby Clegg has her eyes on the T12 200m top spot after securing silver in Beijing.
Rachel Morris defends the handcycling gold medal she won by three clear minutes in Beijing, and Jim ‘the Swim’ Anderson, who has won a medal in every Paralympic Games since Barcelona in 1992, performs in the men’s S2 50m freestyle.
World Boccia No1 Nigel Murray should be in contention in the singles competition, and on the athletics track Bethany Woodward will try to add Paralympic gold to her World Championship crown in the T37 400m.
On the last day of London 2012 the four marathon events take place, and David Weir and Shelly Woods will carry Britain’s medal hopes in the T54 division. Teams will battle it out in the 7-a-side football and wheelchair rugby, before the closing ceremony begins. The ‘Festival of Flame’ will feature Coldplay performing live on stage with an estimated worldwide audience of 750 million people.
C4 is broadcasting unprecedented coverage of the Paralympic Games with around 500 hours being shown on Channel 4, More 4 and three additional live Paralympic Extra channels